What is the Oral Fat Tolerance Test?

The Oral Fat Tolerance Test is a test used to determine the postprandial level of triglycerides in blood serum after eating a standardized LIPOTEST meal, which contains strictly defined amounts of saturated fats (75 g), carbohydrates (25 g) and proteins (10 g).

Determining postprandial triglyceride levels is very important because, as mentioned in the previous tab, fasting triglyceride levels do not answer the question of how triglyceride levels behave in the postprandial period.

The need to determine postprandial triglyceride levels is supported by clinical studies: The Women’s Health Study, the Copenhagen City Heart Study, the Physicians Health Study, the Apolipoprotein-related Mortality Risk Study, the second Northwick Park Heart Study, the Norwegian Study and the ARIC study.

In the area of postprandial triglyceride level determination, until recently there was no consensus in the scientific community. However, after a meta-analysis of 113 studies, a group of experts standardized the methods of test evaluation and published the first recommendations in 2011. Additionally, the same group of experts analyzed 450 medical publications that appeared in the PubMed database between January 2011 and November 2018, which addressed issues related to the assessment of the usefulness of OFTT. As a result of these analyses, in 2019, another position of the international panel of experts was published in the Current Vascular Pharmacology journal, which confirmed the conclusions from 2011 and defined the groups of patients in whom OFTT should be performed.

The method for standardizing and evaluating postprandial triglyceride measurement was defined and approved by an expert panel.

Postprandial triglyceride measurement should be performed at a specified time after consuming a standardized meal.

The Oral Fat Tolerance Test is performed as follows:

• After 10-12 hours of fasting, the patient takes a standardized LIPOTEST meal containing precisely defined amounts of saturated fats, carbohydrates and proteins.
• Then, 4 hours after the meal, we take a blood sample to assess the level of triglycerides in the blood serum.
• A triglyceride level after 4 hours higher than 220 mg/dl means the test is positive.

LIPOTEST meal is a diagnostic meal used only to perform OFTT.

LIPOTEST meal is authorized by EOF and patented in its commercial form by D, Genomeres Medical Research. It is the only meal of its kind in the world.